Reactive Drug Metabolites

Content:
Chapter 1 Origin and Historical Perspective on Reactive Metabolites (pages 1–12):
Chapter 2 Role of Reactive Metabolites in Genotoxicity (pages 13–42):
Chapter 3 Bioactivation and Inactivation of Cytochrome P450 and Other Drug?Metabolizing Enzymes (pages 43–70):
Chapter 4 Role of Reactive Metabolites in Drug?Induced Toxicity – The Tale of Acetaminophen, Halothane, Hydralazine, and Tienilic Acid (pages 71–92):
Chapter 5 Pathways of Reactive Metabolite Formation with Toxicophores/?Structural Alerts (pages 93–129):
Chapter 6 Intrinsically Electrophilic Compounds as a Liability in Drug Discovery (pages 131–143):
Chapter 7 Role of Reactive Metabolites in Pharmacological Action (pages 145–183):
Chapter 8 Retrospective Analysis of Structure–Toxicity Relationships of Drugs (pages 185–202):
Chapter 9 Bioactivation and Natural Products (pages 203–224):
Chapter 10 Experimental Approaches to Reactive Metabolite Detection (pages 225–240):
Chapter 11 Case Studies on Eliminating/Reducing Reactive Metabolite Formation in Drug Discovery (pages 241–268):
Chapter 12 Structural Alert and Reactive Metabolite Analysis for the Top 200 Drugs in the US Market by Prescription (pages 269–312):
Chapter 13 Mitigating Toxicity Risks with Affinity Labeling Drug Candidates (pages 313–334):
Chapter 14 Dealing with Reactive Metabolite–Positive Compounds in Drug Discovery (pages 335–355):
Chapter 15 Managing IADRs – a Risk–Benefit Analysis (pages 357–375):